Uric acid as a potential disease modifier in patients with multiple system atrophy
Identifieur interne : 000104 ( Main/Exploration ); précédent : 000103; suivant : 000105Uric acid as a potential disease modifier in patients with multiple system atrophy
Auteurs : Ji E. Lee [Corée du Sud] ; Sook K. Song [Corée du Sud] ; Young H. Sohn [Corée du Sud] ; Phil Hyu Lee [Corée du Sud]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-07.
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Abstract
Background:: Recent studies have suggested that mitochondrial dysfunction and oxidative stress play a key role in the pathogenesis of multiple system atrophy. Methods:: We evaluated the influence of serum uric acid levels on disease progression in 52 patients with multiple system atrophy using changes in the annualized Unified Multiple System Atrophy Rating Scale scores. Results:: The mean annualized Unified Multiple System Atrophy Rating Scale changes were significantly lower in patients with the highest uric acid quartile compared with those with the lowest quartile (8.4 ± 5.1 vs 20.2 ± 16.0, P = .038). Serum uric acid levels had a significant negative correlation with the annualized Unified Multiple System Atrophy Rating Scale changes (r = −0.40, P = .004). Multiple linear regression analysis showed that only serum uric acid concentration was significantly correlated with the annualized Unified Multiple System Atrophy Rating Scale changes (β = −2.687, P = .011). Conclusions:: These data suggest that serum uric acid may act as a potential disease modifier in multiple system atrophy. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23556
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Sohn</name></author><author><name sortKey="Lee, Phil Hyu" sort="Lee, Phil Hyu" uniqKey="Lee P" first="Phil Hyu" last="Lee">Phil Hyu Lee</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9FDA783E1D171D8F0B82711CD9D73384D43B8E33</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23556</idno><idno type="url">https://api.istex.fr/document/9FDA783E1D171D8F0B82711CD9D73384D43B8E33/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001488</idno><idno type="wicri:Area/Main/Curation">001267</idno><idno type="wicri:Area/Main/Exploration">000104</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Uric acid as a potential disease modifier in patients with multiple system atrophy</title><author><name sortKey="Lee, Ji E" sort="Lee, Ji E" uniqKey="Lee J" first="Ji E." last="Lee">Ji E. Lee</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Song, Sook K" sort="Song, Sook K" uniqKey="Song S" first="Sook K." last="Song">Sook K. Song</name><affiliation wicri:level="1"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Jeju University College of Medicine, Jeju</wicri:regionArea><wicri:noRegion>Jeju</wicri:noRegion></affiliation></author><author><name sortKey="Sohn, Young H" sort="Sohn, Young H" uniqKey="Sohn Y" first="Young H." last="Sohn">Young H. Sohn</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author><author><name sortKey="Lee, Phil Hyu" sort="Lee, Phil Hyu" uniqKey="Lee P" first="Phil Hyu" last="Lee">Phil Hyu Lee</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Neurology, Yonsei University College of Medicine, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Severance Biomedical Science Institute, Yonsei University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-07">2011-07</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1533">1533</biblScope><biblScope unit="page" to="1536">1536</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">9FDA783E1D171D8F0B82711CD9D73384D43B8E33</idno><idno type="DOI">10.1002/mds.23556</idno><idno type="ArticleID">MDS23556</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>multiple system atrophy</term><term>progression</term><term>uric acid</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Recent studies have suggested that mitochondrial dysfunction and oxidative stress play a key role in the pathogenesis of multiple system atrophy. Methods:: We evaluated the influence of serum uric acid levels on disease progression in 52 patients with multiple system atrophy using changes in the annualized Unified Multiple System Atrophy Rating Scale scores. Results:: The mean annualized Unified Multiple System Atrophy Rating Scale changes were significantly lower in patients with the highest uric acid quartile compared with those with the lowest quartile (8.4 ± 5.1 vs 20.2 ± 16.0, P = .038). Serum uric acid levels had a significant negative correlation with the annualized Unified Multiple System Atrophy Rating Scale changes (r = −0.40, P = .004). Multiple linear regression analysis showed that only serum uric acid concentration was significantly correlated with the annualized Unified Multiple System Atrophy Rating Scale changes (β = −2.687, P = .011). Conclusions:: These data suggest that serum uric acid may act as a potential disease modifier in multiple system atrophy. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Lee, Ji E" sort="Lee, Ji E" uniqKey="Lee J" first="Ji E." last="Lee">Ji E. Lee</name></noRegion><name sortKey="Lee, Phil Hyu" sort="Lee, Phil Hyu" uniqKey="Lee P" first="Phil Hyu" last="Lee">Phil Hyu Lee</name><name sortKey="Lee, Phil Hyu" sort="Lee, Phil Hyu" uniqKey="Lee P" first="Phil Hyu" last="Lee">Phil Hyu Lee</name><name sortKey="Sohn, Young H" sort="Sohn, Young H" uniqKey="Sohn Y" first="Young H." last="Sohn">Young H. Sohn</name><name sortKey="Song, Sook K" sort="Song, Sook K" uniqKey="Song S" first="Sook K." last="Song">Sook K. Song</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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